Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma

Tahani Abduljabbar Nasser; Kareem Hamed Ghali; Hameed Naeem Mousa

doi:doi:10.11648/j.ajhr.20170502.14

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Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma

Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa

Published in American Journal of Health Research (Volume 5, Issue 2)

Received: 17 January 2017 Accepted: 18 February 2017 Published: 9 March 2017

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Abstract

The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p<0.05). On the other hand, the positive expression of EGFR was increased but did not reach to significantly difference in thyroid carcinoma in comparison with neither benign neoplasms nor control group (p>0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.

Published in	American Journal of Health Research (Volume 5, Issue 2)
DOI	10.11648/j.ajhr.20170502.14
Page(s)	44-49
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Thyroid Cancer, TGFα, EGFR and Immunohistochemistry

References

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APA Style

Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa. (2017). Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. American Journal of Health Research, 5(2), 44-49. https://doi.org/10.11648/j.ajhr.20170502.14

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ACS Style

Tahani Abduljabbar Nasser; Kareem Hamed Ghali; Hameed Naeem Mousa. Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. Am. J. Health Res. 2017, 5(2), 44-49. doi: 10.11648/j.ajhr.20170502.14

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AMA Style

Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa. Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. Am J Health Res. 2017;5(2):44-49. doi: 10.11648/j.ajhr.20170502.14

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@article{10.11648/j.ajhr.20170502.14,
  author = {Tahani Abduljabbar Nasser and Kareem Hamed Ghali and Hameed Naeem Mousa},
  title = {Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma},
  journal = {American Journal of Health Research},
  volume = {5},
  number = {2},
  pages = {44-49},
  doi = {10.11648/j.ajhr.20170502.14},
  url = {https://doi.org/10.11648/j.ajhr.20170502.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170502.14},
  abstract = {The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.},
 year = {2017}
}

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TY  - JOUR
T1  - Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma
AU  - Tahani Abduljabbar Nasser
AU  - Kareem Hamed Ghali
AU  - Hameed Naeem Mousa
Y1  - 2017/03/09
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhr.20170502.14
DO  - 10.11648/j.ajhr.20170502.14
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 44
EP  - 49
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20170502.14
AB  - The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.
VL  - 5
IS  - 2
ER  -

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Author Information

Tahani Abduljabbar Nasser

Department of Biology, College of Science, Wasit University, Wasit, Iraq
Kareem Hamed Ghali

Department of Biology, College of Science, Wasit University, Wasit, Iraq
Hameed Naeem Mousa

Department of Pathology and Forensic Medicine, College of Medicine, Thi Qar University, Thi Qar, Iraq

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APA Style

Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa. (2017). Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. American Journal of Health Research, 5(2), 44-49. https://doi.org/10.11648/j.ajhr.20170502.14

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ACS Style

Tahani Abduljabbar Nasser; Kareem Hamed Ghali; Hameed Naeem Mousa. Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. Am. J. Health Res. 2017, 5(2), 44-49. doi: 10.11648/j.ajhr.20170502.14

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AMA Style

Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa. Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. Am J Health Res. 2017;5(2):44-49. doi: 10.11648/j.ajhr.20170502.14

Copy | Download

@article{10.11648/j.ajhr.20170502.14,
  author = {Tahani Abduljabbar Nasser and Kareem Hamed Ghali and Hameed Naeem Mousa},
  title = {Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma},
  journal = {American Journal of Health Research},
  volume = {5},
  number = {2},
  pages = {44-49},
  doi = {10.11648/j.ajhr.20170502.14},
  url = {https://doi.org/10.11648/j.ajhr.20170502.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170502.14},
  abstract = {The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma
AU  - Tahani Abduljabbar Nasser
AU  - Kareem Hamed Ghali
AU  - Hameed Naeem Mousa
Y1  - 2017/03/09
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhr.20170502.14
DO  - 10.11648/j.ajhr.20170502.14
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 44
EP  - 49
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20170502.14
AB  - The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.
VL  - 5
IS  - 2
ER  -

Copy | Download