Serum Neopterin Level in Early Onset Neonatal Sepsis

Fathia Sayed El Nemer; Dina Abdel Razek Midan; Ahmed Fouad Mohamed

doi:doi:10.11648/j.ajbio.20150303.13

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Serum Neopterin Level in Early Onset Neonatal Sepsis

Fathia Sayed El Nemer, Dina Abdel Razek Midan, Ahmed Fouad Mohamed

Published in American Journal of BioScience (Volume 3, Issue 3)

Received: 17 April 2015 Accepted: 22 April 2015 Published: 5 May 2015

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Abstract

Objective: The Aim of the study is to evaluate the diagnostic and prognostic values of serum neopterin level in neonatal sepsis and to evaluate risk factors for neonatal sepsis in neonatal intensive care unit of Menoufyia University hospital. Background: Neonatal sepsis has been used to describe the systemic response to infection in the newborn infant younger than one month age. Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased concentration of neopterin in serum is observed in conditions with involvement of cellmediated immune response. Methods: Our study was conducted on 88 neonates recruited from NICU of and divided to Group І (suspected sepsis), It includes 35 neonates with symptoms and signs suggestive of sepsis or at high risk of infection. Group ІІ (proven sepsis), It includes 38 neonates who are septic with clinical picture of sepsis and laboratory data showing sepsis, Group Ш (Controls), It includes 15 healthy neonates with no evidence of sepsis, all groups were subjected to history taking, clinical examination and laboratory Investigations included complete blood count, blood cultures, Quantitative C-reactive protein (CRP) and Serum neopterin level. Results: Serum neopterin was significantly high in Group I (44.46±24.72) and Group II (108.37±22.38) than in controls and the best cutoff value of serum neopterin to detect sepsis is 70.56 nmol/L with sensitivity 94.7% and specificity 88.6% .and that neopetrin correlated well with mortalities due to sepsis. Conclusion: Neopterin found to be a diagnostic and prognostic factor in patients with sepsis.

Published in	American Journal of BioScience (Volume 3, Issue 3)
DOI	10.11648/j.ajbio.20150303.13
Page(s)	80-86
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Neopterin, C-Reactive Protein (Crp), Neonatal Sepsis

References

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[5]	Vineet Bhandari, Chao Wang, Christine Rinder and Henry Rinder. Hematologic Profile of Sepsis in Neonates: Neutrophil CD64 as a Diagnostic Marker. Pediatrics 2008;121;129-134.
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[18]	Fergany AL .Serum cortisol and thyroid hormone levels in neonates with sepsis. Thesis submitted for partial fulfillment of Master degree in Pediatrics, Faculty of Medicine, Ain- Shams University. Supervised by El Barbari MN, Imam SS, Shaheen KY-2006.
[19]	El-Raggal NM, El-Barbary MN, Youssef MF, El-Mansy HA. Neutrophil surface antigens CD11b and CD64 expression: a potential predictor of early-onset neonatal sepsis. Egypt J Pediatr Allergy Immunol, 2004; 2 (2): 90-100.
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APA Style

Fathia Sayed El Nemer, Dina Abdel Razek Midan, Ahmed Fouad Mohamed. (2015). Serum Neopterin Level in Early Onset Neonatal Sepsis. American Journal of BioScience, 3(3), 80-86. https://doi.org/10.11648/j.ajbio.20150303.13

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ACS Style

Fathia Sayed El Nemer; Dina Abdel Razek Midan; Ahmed Fouad Mohamed. Serum Neopterin Level in Early Onset Neonatal Sepsis. Am. J. BioScience 2015, 3(3), 80-86. doi: 10.11648/j.ajbio.20150303.13

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AMA Style

Fathia Sayed El Nemer, Dina Abdel Razek Midan, Ahmed Fouad Mohamed. Serum Neopterin Level in Early Onset Neonatal Sepsis. Am J BioScience. 2015;3(3):80-86. doi: 10.11648/j.ajbio.20150303.13

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@article{10.11648/j.ajbio.20150303.13,
  author = {Fathia Sayed El Nemer and Dina Abdel Razek Midan and Ahmed Fouad Mohamed},
  title = {Serum Neopterin Level in Early Onset Neonatal Sepsis},
  journal = {American Journal of BioScience},
  volume = {3},
  number = {3},
  pages = {80-86},
  doi = {10.11648/j.ajbio.20150303.13},
  url = {https://doi.org/10.11648/j.ajbio.20150303.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20150303.13},
  abstract = {Objective: The Aim of the study is to evaluate the diagnostic and prognostic values of serum neopterin level in neonatal sepsis and to evaluate risk factors for neonatal sepsis in neonatal intensive care unit of Menoufyia University hospital. Background: Neonatal sepsis has been used to describe the systemic response to infection in the newborn infant younger than one month age. Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased concentration of neopterin in serum is observed in conditions with involvement of cellmediated immune response. Methods: Our study was conducted on 88 neonates recruited from NICU of and divided to Group І (suspected sepsis), It includes 35 neonates with symptoms and signs suggestive of sepsis or at high risk of infection. Group ІІ (proven sepsis), It includes 38 neonates who are septic with clinical picture of sepsis and laboratory data showing sepsis, Group Ш (Controls), It includes 15 healthy neonates with no evidence of sepsis, all groups were subjected to history taking, clinical examination and laboratory Investigations included complete blood count, blood cultures, Quantitative C-reactive protein (CRP) and Serum neopterin level. Results: Serum neopterin was significantly high in Group I (44.46±24.72) and Group II (108.37±22.38) than in controls and the best cutoff value of serum neopterin to detect sepsis is 70.56 nmol/L with sensitivity 94.7% and specificity 88.6% .and that neopetrin correlated well with mortalities due to sepsis. Conclusion: Neopterin found to be a diagnostic and prognostic factor in patients with sepsis.},
 year = {2015}
}

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TY  - JOUR
T1  - Serum Neopterin Level in Early Onset Neonatal Sepsis
AU  - Fathia Sayed El Nemer
AU  - Dina Abdel Razek Midan
AU  - Ahmed Fouad Mohamed
Y1  - 2015/05/05
PY  - 2015
N1  - https://doi.org/10.11648/j.ajbio.20150303.13
DO  - 10.11648/j.ajbio.20150303.13
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 80
EP  - 86
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20150303.13
AB  - Objective: The Aim of the study is to evaluate the diagnostic and prognostic values of serum neopterin level in neonatal sepsis and to evaluate risk factors for neonatal sepsis in neonatal intensive care unit of Menoufyia University hospital. Background: Neonatal sepsis has been used to describe the systemic response to infection in the newborn infant younger than one month age. Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased concentration of neopterin in serum is observed in conditions with involvement of cellmediated immune response. Methods: Our study was conducted on 88 neonates recruited from NICU of and divided to Group І (suspected sepsis), It includes 35 neonates with symptoms and signs suggestive of sepsis or at high risk of infection. Group ІІ (proven sepsis), It includes 38 neonates who are septic with clinical picture of sepsis and laboratory data showing sepsis, Group Ш (Controls), It includes 15 healthy neonates with no evidence of sepsis, all groups were subjected to history taking, clinical examination and laboratory Investigations included complete blood count, blood cultures, Quantitative C-reactive protein (CRP) and Serum neopterin level. Results: Serum neopterin was significantly high in Group I (44.46±24.72) and Group II (108.37±22.38) than in controls and the best cutoff value of serum neopterin to detect sepsis is 70.56 nmol/L with sensitivity 94.7% and specificity 88.6% .and that neopetrin correlated well with mortalities due to sepsis. Conclusion: Neopterin found to be a diagnostic and prognostic factor in patients with sepsis.
VL  - 3
IS  - 3
ER  -

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Author Information

Fathia Sayed El Nemer

Pediatric Department, Faculty of Medicine, Menoufyia University, Shebin al-Kom, Egypt
Dina Abdel Razek Midan

Pediatric Department, Faculty of Medicine, Menoufyia University, Shebin al-Kom, Egypt
Ahmed Fouad Mohamed

Pediatric Department, Faculty of Medicine, Menoufyia University, Shebin al-Kom, Egypt

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APA Style

Fathia Sayed El Nemer, Dina Abdel Razek Midan, Ahmed Fouad Mohamed. (2015). Serum Neopterin Level in Early Onset Neonatal Sepsis. American Journal of BioScience, 3(3), 80-86. https://doi.org/10.11648/j.ajbio.20150303.13

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ACS Style

Fathia Sayed El Nemer; Dina Abdel Razek Midan; Ahmed Fouad Mohamed. Serum Neopterin Level in Early Onset Neonatal Sepsis. Am. J. BioScience 2015, 3(3), 80-86. doi: 10.11648/j.ajbio.20150303.13

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AMA Style

Fathia Sayed El Nemer, Dina Abdel Razek Midan, Ahmed Fouad Mohamed. Serum Neopterin Level in Early Onset Neonatal Sepsis. Am J BioScience. 2015;3(3):80-86. doi: 10.11648/j.ajbio.20150303.13

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@article{10.11648/j.ajbio.20150303.13,
  author = {Fathia Sayed El Nemer and Dina Abdel Razek Midan and Ahmed Fouad Mohamed},
  title = {Serum Neopterin Level in Early Onset Neonatal Sepsis},
  journal = {American Journal of BioScience},
  volume = {3},
  number = {3},
  pages = {80-86},
  doi = {10.11648/j.ajbio.20150303.13},
  url = {https://doi.org/10.11648/j.ajbio.20150303.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20150303.13},
  abstract = {Objective: The Aim of the study is to evaluate the diagnostic and prognostic values of serum neopterin level in neonatal sepsis and to evaluate risk factors for neonatal sepsis in neonatal intensive care unit of Menoufyia University hospital. Background: Neonatal sepsis has been used to describe the systemic response to infection in the newborn infant younger than one month age. Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased concentration of neopterin in serum is observed in conditions with involvement of cellmediated immune response. Methods: Our study was conducted on 88 neonates recruited from NICU of and divided to Group І (suspected sepsis), It includes 35 neonates with symptoms and signs suggestive of sepsis or at high risk of infection. Group ІІ (proven sepsis), It includes 38 neonates who are septic with clinical picture of sepsis and laboratory data showing sepsis, Group Ш (Controls), It includes 15 healthy neonates with no evidence of sepsis, all groups were subjected to history taking, clinical examination and laboratory Investigations included complete blood count, blood cultures, Quantitative C-reactive protein (CRP) and Serum neopterin level. Results: Serum neopterin was significantly high in Group I (44.46±24.72) and Group II (108.37±22.38) than in controls and the best cutoff value of serum neopterin to detect sepsis is 70.56 nmol/L with sensitivity 94.7% and specificity 88.6% .and that neopetrin correlated well with mortalities due to sepsis. Conclusion: Neopterin found to be a diagnostic and prognostic factor in patients with sepsis.},
 year = {2015}
}

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TY  - JOUR
T1  - Serum Neopterin Level in Early Onset Neonatal Sepsis
AU  - Fathia Sayed El Nemer
AU  - Dina Abdel Razek Midan
AU  - Ahmed Fouad Mohamed
Y1  - 2015/05/05
PY  - 2015
N1  - https://doi.org/10.11648/j.ajbio.20150303.13
DO  - 10.11648/j.ajbio.20150303.13
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 80
EP  - 86
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20150303.13
AB  - Objective: The Aim of the study is to evaluate the diagnostic and prognostic values of serum neopterin level in neonatal sepsis and to evaluate risk factors for neonatal sepsis in neonatal intensive care unit of Menoufyia University hospital. Background: Neonatal sepsis has been used to describe the systemic response to infection in the newborn infant younger than one month age. Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased concentration of neopterin in serum is observed in conditions with involvement of cellmediated immune response. Methods: Our study was conducted on 88 neonates recruited from NICU of and divided to Group І (suspected sepsis), It includes 35 neonates with symptoms and signs suggestive of sepsis or at high risk of infection. Group ІІ (proven sepsis), It includes 38 neonates who are septic with clinical picture of sepsis and laboratory data showing sepsis, Group Ш (Controls), It includes 15 healthy neonates with no evidence of sepsis, all groups were subjected to history taking, clinical examination and laboratory Investigations included complete blood count, blood cultures, Quantitative C-reactive protein (CRP) and Serum neopterin level. Results: Serum neopterin was significantly high in Group I (44.46±24.72) and Group II (108.37±22.38) than in controls and the best cutoff value of serum neopterin to detect sepsis is 70.56 nmol/L with sensitivity 94.7% and specificity 88.6% .and that neopetrin correlated well with mortalities due to sepsis. Conclusion: Neopterin found to be a diagnostic and prognostic factor in patients with sepsis.
VL  - 3
IS  - 3
ER  -

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