Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children

Wildana Azikin; Amiruddin Laompo; Husein Albar; Dasril Daud

doi:doi:10.11648/j.ajhr.20170501.12

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Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children

Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud

Published in American Journal of Health Research (Volume 5, Issue 1)

Received: 24 January 2016 Accepted: 4 February 2016 Published: 15 February 2017

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Abstract

Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.

Published in	American Journal of Health Research (Volume 5, Issue 1)
DOI	10.11648/j.ajhr.20170501.12
Page(s)	7-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Matrix Metalloproteinase-9 (MMP-9), Tuberculosis Exposed Children, Tuberculosis Infected Children

References

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[6]	Stuelten CH., Byfield SD., Arany PR., Karpova TS., Stevenson W. G. S., Roberts A. B. Breast cancer cells induce stromal fibroblast to express MMP-9 via secretion of TNF-α and TGF-β. Journal of cell science 118. 2143-2153. 2005.
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[14]	Kilic Z., Ucar B., Ozdemir G., Colak O., Bal C., Ertugrul T. Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinase levels in pediatrics patients with congenital heart disease: relationship to cardiac functions. Anadolu Kardiyol Derg: 14: 531-41. 2014.
[15]	Lee CY., Shim HS., Lee S., Lee JG., Kim DJ., Chung KY. Prognostic effect of matrix metalloproteinase-9 in patients with resected non small cell lung cancer. Journal of cardiothoracic surgery 10; 44. 2015.
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APA Style

Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud. (2017). Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. American Journal of Health Research, 5(1), 7-10. https://doi.org/10.11648/j.ajhr.20170501.12

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ACS Style

Wildana Azikin; Amiruddin Laompo; Husein Albar; Dasril Daud. Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. Am. J. Health Res. 2017, 5(1), 7-10. doi: 10.11648/j.ajhr.20170501.12

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AMA Style

Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud. Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. Am J Health Res. 2017;5(1):7-10. doi: 10.11648/j.ajhr.20170501.12

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@article{10.11648/j.ajhr.20170501.12,
  author = {Wildana Azikin and Amiruddin Laompo and Husein Albar and Dasril Daud},
  title = {Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children},
  journal = {American Journal of Health Research},
  volume = {5},
  number = {1},
  pages = {7-10},
  doi = {10.11648/j.ajhr.20170501.12},
  url = {https://doi.org/10.11648/j.ajhr.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170501.12},
  abstract = {Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.},
 year = {2017}
}

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TY  - JOUR
T1  - Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children
AU  - Wildana Azikin
AU  - Amiruddin Laompo
AU  - Husein Albar
AU  - Dasril Daud
Y1  - 2017/02/15
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhr.20170501.12
DO  - 10.11648/j.ajhr.20170501.12
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 7
EP  - 10
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20170501.12
AB  - Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.
VL  - 5
IS  - 1
ER  -

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Author Information

Wildana Azikin

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
Amiruddin Laompo

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
Husein Albar

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia
Dasril Daud

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia

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APA Style

Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud. (2017). Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. American Journal of Health Research, 5(1), 7-10. https://doi.org/10.11648/j.ajhr.20170501.12

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ACS Style

Wildana Azikin; Amiruddin Laompo; Husein Albar; Dasril Daud. Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. Am. J. Health Res. 2017, 5(1), 7-10. doi: 10.11648/j.ajhr.20170501.12

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AMA Style

Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud. Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. Am J Health Res. 2017;5(1):7-10. doi: 10.11648/j.ajhr.20170501.12

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@article{10.11648/j.ajhr.20170501.12,
  author = {Wildana Azikin and Amiruddin Laompo and Husein Albar and Dasril Daud},
  title = {Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children},
  journal = {American Journal of Health Research},
  volume = {5},
  number = {1},
  pages = {7-10},
  doi = {10.11648/j.ajhr.20170501.12},
  url = {https://doi.org/10.11648/j.ajhr.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170501.12},
  abstract = {Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.},
 year = {2017}
}

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TY  - JOUR
T1  - Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children
AU  - Wildana Azikin
AU  - Amiruddin Laompo
AU  - Husein Albar
AU  - Dasril Daud
Y1  - 2017/02/15
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhr.20170501.12
DO  - 10.11648/j.ajhr.20170501.12
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 7
EP  - 10
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20170501.12
AB  - Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.
VL  - 5
IS  - 1
ER  -

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