Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients

Mathias Abiodun Emokpae; Rossy Jane Umeadi

doi:doi:10.11648/j.ajbls.20150303.16

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Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients

Mathias Abiodun Emokpae, Rossy Jane Umeadi

Published in American Journal of Biomedical and Life Sciences (Volume 3, Issue 3)

Received: 15 April 2015 Accepted: 29 April 2015 Published: 13 May 2015

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Abstract

Background/objective: The role of foetal haemoglobin (HbF) on the modulation of clinical manifestations in sickle cell disease is well known but there is inconsistency as to the levels of HbF that may protective against the development of liver disease. This study evaluates the impact of HbF on biochemical markers of liver function in sickle cell disease (SCD) patients in steady clinical state. Materials and Methods: Liver function tests: aspartate amino transferase, alanine amino transferase, alkaline phosphatase, bilirubin and proteins as well as HbF were assayed in SCD patients using colorimetric methods. Results: Out of 100 SCD patients, 24% had high (>5%) HbF while 76% had low (<4.9%) HbF levels. Those subjects with high HbF had lower (p<0.001) levels of measured variables except albumin which was higher compared to levels in those with low HbF. HbF correlated negatively with the measured variables except albumin. Conclusion: The SCD patients with high HbF had lower levels of the measured variables compared to those with low levels of HbF. High HbF levels (>5%) may be protective against the development of liver pathology in SCD patients in steady clinical state.

Published in	American Journal of Biomedical and Life Sciences (Volume 3, Issue 3)
DOI	10.11648/j.ajbls.20150303.16
Page(s)	61-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Foetal Haemoglobin, Liver Disease, Liver Function Tests, Sickle Cell Disease, Steady Clinical State

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APA Style

Mathias Abiodun Emokpae, Rossy Jane Umeadi. (2015). Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients. American Journal of Biomedical and Life Sciences, 3(3), 61-66. https://doi.org/10.11648/j.ajbls.20150303.16

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ACS Style

Mathias Abiodun Emokpae; Rossy Jane Umeadi. Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients. Am. J. Biomed. Life Sci. 2015, 3(3), 61-66. doi: 10.11648/j.ajbls.20150303.16

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AMA Style

Mathias Abiodun Emokpae, Rossy Jane Umeadi. Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients. Am J Biomed Life Sci. 2015;3(3):61-66. doi: 10.11648/j.ajbls.20150303.16

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@article{10.11648/j.ajbls.20150303.16,
  author = {Mathias Abiodun Emokpae and Rossy Jane Umeadi},
  title = {Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {3},
  number = {3},
  pages = {61-66},
  doi = {10.11648/j.ajbls.20150303.16},
  url = {https://doi.org/10.11648/j.ajbls.20150303.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20150303.16},
  abstract = {Background/objective: The role of foetal haemoglobin (HbF) on the modulation of clinical manifestations in sickle cell disease is well known but there is inconsistency as to the levels of HbF that may protective against the development of liver disease. This study evaluates the impact of HbF on biochemical markers of liver function in sickle cell disease (SCD) patients in steady clinical state. Materials and Methods: Liver function tests: aspartate amino transferase, alanine amino transferase, alkaline phosphatase, bilirubin and proteins as well as HbF were assayed in SCD patients using colorimetric methods. Results: Out of 100 SCD patients, 24% had high (>5%) HbF while 76% had low (5%) may be protective against the development of liver pathology in SCD patients in steady clinical state.},
 year = {2015}
}

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TY  - JOUR
T1  - Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients
AU  - Mathias Abiodun Emokpae
AU  - Rossy Jane Umeadi
Y1  - 2015/05/13
PY  - 2015
N1  - https://doi.org/10.11648/j.ajbls.20150303.16
DO  - 10.11648/j.ajbls.20150303.16
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 61
EP  - 66
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20150303.16
AB  - Background/objective: The role of foetal haemoglobin (HbF) on the modulation of clinical manifestations in sickle cell disease is well known but there is inconsistency as to the levels of HbF that may protective against the development of liver disease. This study evaluates the impact of HbF on biochemical markers of liver function in sickle cell disease (SCD) patients in steady clinical state. Materials and Methods: Liver function tests: aspartate amino transferase, alanine amino transferase, alkaline phosphatase, bilirubin and proteins as well as HbF were assayed in SCD patients using colorimetric methods. Results: Out of 100 SCD patients, 24% had high (>5%) HbF while 76% had low (5%) may be protective against the development of liver pathology in SCD patients in steady clinical state.
VL  - 3
IS  - 3
ER  -

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Author Information

Mathias Abiodun Emokpae

Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria
Rossy Jane Umeadi

Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria

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APA Style

Mathias Abiodun Emokpae, Rossy Jane Umeadi. (2015). Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients. American Journal of Biomedical and Life Sciences, 3(3), 61-66. https://doi.org/10.11648/j.ajbls.20150303.16

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ACS Style

Mathias Abiodun Emokpae; Rossy Jane Umeadi. Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients. Am. J. Biomed. Life Sci. 2015, 3(3), 61-66. doi: 10.11648/j.ajbls.20150303.16

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AMA Style

Mathias Abiodun Emokpae, Rossy Jane Umeadi. Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients. Am J Biomed Life Sci. 2015;3(3):61-66. doi: 10.11648/j.ajbls.20150303.16

Copy | Download

@article{10.11648/j.ajbls.20150303.16,
  author = {Mathias Abiodun Emokpae and Rossy Jane Umeadi},
  title = {Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {3},
  number = {3},
  pages = {61-66},
  doi = {10.11648/j.ajbls.20150303.16},
  url = {https://doi.org/10.11648/j.ajbls.20150303.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20150303.16},
  abstract = {Background/objective: The role of foetal haemoglobin (HbF) on the modulation of clinical manifestations in sickle cell disease is well known but there is inconsistency as to the levels of HbF that may protective against the development of liver disease. This study evaluates the impact of HbF on biochemical markers of liver function in sickle cell disease (SCD) patients in steady clinical state. Materials and Methods: Liver function tests: aspartate amino transferase, alanine amino transferase, alkaline phosphatase, bilirubin and proteins as well as HbF were assayed in SCD patients using colorimetric methods. Results: Out of 100 SCD patients, 24% had high (>5%) HbF while 76% had low (5%) may be protective against the development of liver pathology in SCD patients in steady clinical state.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Impact Assessment of Foetal Haemoglobin on Biochemical Markers of Liver Function in Sickle Cell Disease Patients
AU  - Mathias Abiodun Emokpae
AU  - Rossy Jane Umeadi
Y1  - 2015/05/13
PY  - 2015
N1  - https://doi.org/10.11648/j.ajbls.20150303.16
DO  - 10.11648/j.ajbls.20150303.16
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 61
EP  - 66
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20150303.16
AB  - Background/objective: The role of foetal haemoglobin (HbF) on the modulation of clinical manifestations in sickle cell disease is well known but there is inconsistency as to the levels of HbF that may protective against the development of liver disease. This study evaluates the impact of HbF on biochemical markers of liver function in sickle cell disease (SCD) patients in steady clinical state. Materials and Methods: Liver function tests: aspartate amino transferase, alanine amino transferase, alkaline phosphatase, bilirubin and proteins as well as HbF were assayed in SCD patients using colorimetric methods. Results: Out of 100 SCD patients, 24% had high (>5%) HbF while 76% had low (5%) may be protective against the development of liver pathology in SCD patients in steady clinical state.
VL  - 3
IS  - 3
ER  -

Copy | Download